Job Description
Fusion Pharmaceuticals, a member of the AstraZeneca Group , is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs. The Research Associate, Radiochemistry role is an on site, lab position in Hamilton, Ontario.
Responsibilities Responsibilities and job tasks (including, but not limited to): - Effectively execute routine radiolabeling productions for a range of targeting moieties (small molecules to mAbs) and radioisotopes in support of biological studies as a part of the Discovery team
- Contribute to the preparation, purification and characterization of novel radioconjugates including stability assessments
- Assist in the synthesis of radiolabeling precursors as required
- Analyze and interpret data
- Maintain clear and current records of work within a laboratory notebook
- Contribute to the organization and maintenance of all chemistry laboratories including waste streams in collaboration with operations and health physics teams
- Effectively communicate scientific findings, which may come in the form of writing reports and presentations
Qualifications - Driven radiochemist with a recognized post-secondary education in radiochemistry, inorganic chemistry, organometallic chemistry or a related discipline
- B.S. required, M.S. desired with 2-5 years of relevant laboratory experience
- Excellent troubleshooting skills in the lab, organizational skills and an understanding of the radiopharmaceutical field
- Experience with analytical HPLC method development and Empower software
- Proven ability to work independently with strong communication skills and attention to detail, including proficiency in the English language
- Demonstrable independent research accomplishments
- Excel at working in a fast-paced, collaborative environment as a member of a multidisciplinary team
- Knowledge of good laboratory practices is an asset
- Demonstrated ability to successfully prioritize tasks and manage timelines
- Experience in the safe handling and analysis of radiometal conjugates is desirable
- Experience with bioconjugations and medicinal synthetic chemistry is also desirable
Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
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